A fiber Bragg grating(FBG) high-temperature and high pressure sensor has been designed and fabricated by using the Al2O3 thin-wall tube as a substrate.The test results show that the sensor can withstand a pressure range of 0-45 MPa and a temperature range of -10-300 ℃,and has a pressure sensitivity of 0.0426 nm/MPa and a temperature sensitivity of 0.0112 nm / ℃